Hikaru and Misa from
Macross 
What a rocky startup with both of them hating each other to good friends to over angsting over what the others were thinking.

If it was easy, it would not have been fun to watch.
Yukino and Arima from
Kare Kano 
Their story was both funny and compelling. It
felt real watching the series.
Hubb Lebowski and Cher Degre from
Wolf's Rain 
I think this was the more interesting story thread of the series. Hubb's pursuit to save his ex-wife only to lose her before the end.

The scene where he pulls out the scarf while on the rocks really gets me.
If it can't be expressed in numbers or figures, it is an opinion - Robert Heinlein
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