As much as you'd like to debate all sorts of videos that should or could win, you know a Naruto video will. Or maybe FMA but really it'll probably go Naruto. That narrows it to like... Naruto's Technique beat and... let's see... the other top 50 videos on the org =)
Actually I don't know which ones came out this year but I'm betting the Technique Beat will win (although I don't really want it to

). We're still in the middle of the year though, so it is a bit pointless to say; we're not even done with big convention season after all. Maybe something big will come out of it still eh?
If a comedy video were to do it, I don't know if it came out this year but I would want Lord of the Yen to win (Wizard of Ozaka was awesome and even better at AX, but I think Yen is better for non-convention viewing).
Or maybe we should all vote for a DBZ vid downloaded off Kazaa with consumate lens-flares! @_@