(copied paste from ANN)
Hmmm, so far the fall season has a pretty decent selection that's almost on par with this summer season. But first things first:
Sasameki Koto: I have been eying on this one ever since this got announced, and pretty much followed along the many updates the official website had (now I'm waiting for an animated promo video). This is a romantic comedy involving a rather snarky schoolgirl lesbian (almost like a lesbian version of Kyon

) named Sumika who's in love with a cheerful schoolgirl lesbian, Ushio who's her childhood friend. But Ushio prefers
cute girls much to Sumika's dismay.
This series will feature a rather eccentric cast including an already-established schoolgirl lesbian couple, a total yuri fangirl who thinks Marimite-like relationships are God's most beautiful and pure gifts to the world (ok, I may have exaggerated that part a bit), a delicious trap who's surprisingly not as bothersome, and a
reverse German trap (yeah, you heard me). From what I've read in the manga so far, this series will have good amount of visual comedy including some yuri-related ones that doesn't piss off the fanbase (I'm looking at you, Maria Holic), and it doesn't resort to blatant fanservice. The series does have a penchant of getting serious and somewhat angsty (sometimes it's almost like a mood whiplash). But all in all, this is very enjoyable and hopefully AIC does justice to this series. I'm pretty much banking Sasameki Koto on gaining popularity and more buzz beyond just yuri fans.
(all that text for one series, mwahaha)
To Aru Kagaku no Railgun: There's one thing that's clear and that in To Aru Majutsu no Index Mikoto Misaka is by far the most compelling and entertaining female character in the franchise, and it's no surprise she has her own spin-off series. And it's no doubt just to see what she and her clingy friend Kuroko is up to. From what I heard from the manga readers, the plots are far better in quality, execution, and pacing.
I'm also checking out
Kobato on account it's a CLAMP series done by Madhouse Studios in which that combo never disappointed me, and it looks like it'll invoke the warm, fuzzy feelings I had when I first watched Cardcaptor Sakura. As for mindless entertainment,
Shin Koihime Musou should fit the charm (and I want to see Kan'u's all-female harem grow

).