Looks like a CGI remake of the old Appleseed OAV (movie?) that was based on one of Shirow's manga. IMO, the anime was never that good, and I didn't read the manga, so...can't say anything about that.
"If you believe in yourself, eat all your school, stay on milk, drink your teeth, don't do sleep, and get your eight hours of drugs, you can get WORK!" Paperskunk:...PENIS!!!!!!!!! GIANT PENIS!!!!!!!!!! ERMAC WHAT HAVE YOU DONE!!!!!!!! GIANT JUICY PENIS!!!!!!!!! AHHHHHHHHH MY EYES!!!!!!