Maybe you did something wrong with the uncompressed clip, but you are on the right way because uncompressed footage is good footage to work with.
Try this codec:
http://lags.leetcode.net/codec.html
Lagarith is also a loseless, should work in any Adobe software and has a not as high filsize as other loseless codecs.
Let the codecs settings in VDM for Lagarith as they are and the codec will work best. There isn´t really something to make wrong.