I know of a lot of emotional....... tear jerker, moments in animes. I just got the anime, The Girl Who Lept Through Time, a very interestingly done story of time travel. often humorous, often thoughtful, and in a couple places, really tugs the heart strings. I'll try not to give anything away.
At this point Makoto learns the true dangers of messing with time
Here, at the end, is a heart breaking moment, You could really feel Makoto's hurt, again caused by her heart, and a difference of time. If you haven't seen this 100 minute oav, I'd recommend it.
I'll think of others later