If you're looking to get a job based on the school you're going to then you want something that people in the industry that you're looking at will recognize. UC Berkley comes to mind as a pretty good example. Generally the big name 'art' schools.
The demo reel, as ZarXrax pointed out it critical to getting a job. The demo reel is to the video community as the portfolio is to the graphic artist.
The Demo reel should contain your best work, with the newest stuff near the front since most companies get tons of them and likely won't even finish it if it isn't relevant. Additionally, your demo reel (and you should tailor it to the job you're seeking) should be dynamic and interesting. If you're applying for a job doing architectural animations, or courtroom videos then that's alot different than applying for a job doing commercials for whitewater rafting, or game cutscenes.
While, using anime isn't really a deal breaker, you probably want to avoid doing things that smack of being fan based. For example: you wouldn't want to advertise your star trek uniforms, or mastery of the Klingon language either.
If you want to get an idea of what an acceptable demo reel looks like, check out some of the companies that you're going to be hitting up. ILM, for example has some detailed information on what they want and how they want it. Blizzard is a little less restrictive.
Remember, most of the companies that you're going to be hitting up are getting an assload of submissions; so make sure that you give them everything they need. Include both a video tape, and a DVD of your video. Have your resume, or weblinks easy to access from the DVD, and include a hardcopy of your resume.
Ultimately, unless you're really luck; you want to get some connections. Most of the jobs in any idustry are done by the buddy system. Get some jobs, meet people, and work your connections. If you're dour and an asshole you can expect a short career unless you're mega talented (and even then....) If you are bright, eager and easy to get along with in a high stress environment then you have some better chances.
Hope that helps.



