Posted in the wrong topic.
Read ErMaC's guide for MPEG conversion for some detailed instructions. Click on Guides from your Member Home Page.
Or...since you already know TMPGEnc, go to the AWA VAT site:
http://www.awa-con.com/vat/digital.html
and download their "Sample Settings Files". These are "loaded" as configuration files into TMPGEnc. There are several options. The results are good enough to get a vid shown in the AWA contest (and many other contests as well).